Luces y sombras en la incorporaci??n de la Directiva de servicios

download pdf Luces y sombras en la incorporaci??n de la Directiva de servicios, دانلود Luces y sombras en la incorporaci??n de la Directiva de servicios,Mercedes Fuertes, کتاب های Mercedes Fuertes,Escuela de Administraci??n P??blica de Catalu??a 2011-01-12, لیست کتاب های Escuela de Administraci??n P??blica de Catalu??a 2011-01-12,WorldCat, کتاب های WorldCat

گت بلاگز Internet Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report / دانلود فایل

مشخصات کلی Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report

نویسنده کتاب (Author):

Núñez, Lucía; Crespo-Leiro, María Generosa; Marrón Liñares, Grecia Manuela; Suárez-Fuentetaja, Natalia; Barge-Caballero, Eduardo; Paniagua-Martín, María Jesús; Marzoa Rivas, Raquel; Grille Cancela, Zulaika; Muñiz, Javier; Vázquez-Rodríguez, José Manuel; Hermida-Prieto, Manuel

انتشارات (Publisher):

Via Médica 2016

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

nun%cc%83ez-l-crespo-leiro-mg-marron-lin%cc%83ares-gm-et-al-analysis-of-variants-in-the-hcn4-gene-and-in-three-single-nucleotide-polymorphisms-of-the-cyp3a4-gene-for-association-with-i

موضوع (Subject):

Heart failure       Ivabradine       HCN4       View all subjects      

توضیحات خلاصه (Summary):

[Abstract] Background: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality. The average heart rate (HR) reduction is 8–10 beats, although clinical trials reveal interindividual variability. The aim of the study is to identify variants associated with HR reduction produced by ivabradine in genes involved in the drug metabolism (CYP3A4) or related to the drug target (HCN4). Methods: In an exploratory cohort (n = 11), patients started on ivabradine were genotyped and the HR reduction was studied. Results: The mean HR reduction after the treatment was 18.10 ± 12.26 bpm. The HR reduction was ≥ 15 bpm in 3 patients and > 5 and < 15 bpm in 7 patients. Four synonymous variants, L12L, L520L, P852P, and P1200P, were detected in the HCN4 gene (frequency = 0.045, 0.045, and 0.681, respectively). Moreover, the CYP3A4*1F and CYP3A4*1B were found in one patient each and CYP3A4*1G was presented in 3 patients. Conclusions: This is the first study using an exploratory pharmacogenetic approach that attempts to explain interindividual variability in ivabradine HR reduction. However, more research must be undertaken in order to determine the role of variants in HCN4 and CYP3A4 genes in response to ivabradine.  Read more…

ژانر / فرم:info:eu-repo/semantics/article

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Núñez, Lucía; Crespo-Leiro, María Generosa; Marrón Liñares, Grecia Manuela; Suárez-Fuentetaja, Natalia; Barge-Caballero, Eduardo; Paniagua-Martín, María Jesús; Marzoa Rivas, Raquel; Grille Cancela, Zulaika; Muñiz, Javier; Vázquez-Rodríguez, José Manuel; Hermida-Prieto, Manuel

شناسه OCLC:979265245

Language Note:English

فهرست محتوا:1897-5593 1898-018X http://hdl.handle.net/2183/17552

نویسنده : getblogs